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The student understands the interrelation among (1) input and output of acids and bases, (2) regulation of plasma buffers, and (3) value of plasma pH: Y States the major sources for the input of fixed acids and bases into the body, including metabolic processes and activities of the gastrointestinal tract Y Describes why carbon dioxide levels affect the concentration of hydrogen ions, and differentiates carbon dioxide input (volatile acid) from the input of fixed acids Y States the Henderson-Hasselbalch equation for the carbon dioxide bicarbonate buffer system Y Describes how the input of fixed acids and bases affects the body levels of bicarbonate Y Explains why body levels of carbon dioxide are usually not altered by the input of fixed acids and bases Y Explains why some low pH fluids alkalinize the blood after they are metabolized The student understands the general renal handling of acids and bases: Y Describes the reabsorption of filtered bicarbonate by the proximal tubule, including the role of carbonic anhydrase and apical membrane Na-H antiporters Y Describes how bicarbonate is excreted in response to an alkaline load: The student understands how the kidneys respond to an acid load: Y Describes how excretion of acid and generation of new bicarbonate are linked Y Defines the concept of urinary titratable acidity Y Describes how the titration of filtered buffers is one means of excreting acid Y Describes how the conversion of glutamine to ammonium and subsequent excretion of ammonium accomplishes the goal of excreting acid Y States how total acid excretion is related to titratable acidity and ammonium excretion The student understands the nature of acid-base disturbances and the meaning of compensation: Y Defines the 4 categories of primary acid-base disturbance Y Defines the meaning of compensation Y Describes the renal response to respiratory acid-base disorders Y Describes the respiratory response to changes in arterial pH Y Identifies nonrenal problems that may cause the kidneys to generate a metabolic alkalosis.

<property name="Title" type="string"> Task Count Web Part </property> <property name="ExportMode" type="exportmode"> None </property>

Figure 11.6 Preconfigured Web Parts can be added to a Visual Studio solution using an Empty SharePoint Project Item and then be deployed to the farm.

TIP Given that you should always have at least two DCs in any domain, you should rarely have to use this procedure

Finally, make sure that the .webpart file is deployed to the Web Part Gallery. Edit the elements.xml file so that it looks like listing 11.5.

156 / 9

If you do have to use this procedure, you must rebuild the server Use Procedure DC-28 to promote the server to DC status and then use restart in Directory Services Restore Mode (see above) Once the server is restarted, use Procedure BR-05 to restore System State Data to the server Make sure you access the Advanced features of the restore to select When restoring replicated data sets, mark the restored data as the primary data for all replicas in the Advanced Restore wizard s third screen

<Elements xmlns="http://schemas.microsoft.com/sharepoint/"> <Module Name="TaskCountWebPart" List="113" Url="_catalogs/wp"> <File Path="TaskCountWebPart\Silverlight_Web_Part.webpart" Url="Silverlight_Web_Part.webpart" Type="GhostableInLibrary"> <Property Name="Group" Value="Web Parts in Action"/> </File> </Module> </Elements>

The first thing to edit is the Module element; the List and Url attributes have to be configured so that the Module is targeting the Web Part Gallery. Second, add the Type attribute to the File element and remove the folder name from the Url attribute. Finally, add a Property element to the File element and configure the element to set the Group property of the Web Part. Before deploying the solution, make sure that the Feature of the SharePoint project has its Scope set to Site. Because this Feature is deploying the Web Part to the Web Part Gallery, you can t use the default Scope value (which is Web). When the solution is deployed, the Task Count Web Part can be found in the Web Part Gallery under the category you specified in the element manifest. The Web Part is now preconfigured with the Silverlight application that s deployed with the Feature.

The topic of acid-base physiology has vexed students for generations Understanding acid-base physiology is greatly aided by keeping in mind several fundamental principles outlined below and always viewing any complexities of acid-base regulation through the lens of these fundamentals It is essential for the body to regulate the concentration of free protons in the extracellular fluid (ECF) to a value close to 40 nM (pH 74) in order for proteins exposed to the ECF to function properly This regulation is called acid-base balance The essence of acid-base balance comes down to 2 related processes: (1) Matching the excretion of acid/base equivalents to their input, and (2) regulating the ratio of weak acids to their conjugate bases in buffer systems Matching excretion to input keeps the body content of these substances constant, ie, keeps the body in balance Regulating the ratio of weak acids to their conjugate bases clamps the pH to a constant value that is buffered; ie, is protected against rapid changes in pH Excretion of acid-base equivalents is the job of the kidneys Balancing total-body input and output of acid or base and regulating physiological buffer concentrations are intimately related, but it is easy to lose sight of one perspective while seeing things from the other