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We can now quantify the kidneys contribution to hydrogen ion balance In other words, we can calculate the kidneys net bicarbonate addition to the body or elimination from it This value is, again, identical to the kidneys net excretion of hydrogen ions ( acid ) Such a calculation is made by answering 3 questions: 1 2 How much bicarbonate is excreted in the urine This represents bicarbonate loss from the body It is measured simply by multiplying the urine flow rate by the urinary bicarbonate concentration How much new bicarbonate is contributed to the plasma by secretion of hydrogen ions that combine in the tubular lumen with non-bicarbonate urinary buffers This can be measured by titrating the urine with NaOH to a pH of 74, the pH of the plasma from which the glomerular filtrate originated This simply reverses the events that occurred within the tubular lumen when the tubular fluid was titrated by secreted hydrogen ions Thus, the number of milliequivalents of sodium hydroxide required to raise the pH back to 74 must equal the number of milliequivalents of hydrogen ion added to the tubular fluid that combined with phosphate and organic buffers This value is known as the titratable acid How much new bicarbonate is returned to the plasma by secretion of hydrogen ions that are excreted as ammonium The titratable acid measurement will not titrate hydrogen ions in NH+ because ammonium is such a weak 4 acid with a pK of the ammonia-ammonium reaction so high (92) that titration with alkali to pH 74 will not remove hydrogen ions from NH4+ vb.net ean 13 VB . NET EAN-13 Generator generate, create barcode EAN-13 ...
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